Cell Sheet for
Periodontal Tissue Regeneration

This is a regenerative medicine pipeline product targeting the regeneration of periodontal tissue lost to periodontal disease.

Product Concept and Features

Periodontal disease is an inflammatory disorder caused by periodontal pathogens. It causes gradual destruction of the tissues that support the teeth. It is a major cause of loss of teeth in adults. Conventional therapies mainly focused on removal of pathogenic factors, not on active regeneration of periodontal tissues. Periodontal Ligament Stem Cell Sheet is based on an innovative concept. It uses the periodontal membrane cells that are associated with the regeneration of both teeth (cementum) and the gums. This cell sheet is manufactured using temperature-responsive cell cultureware and is transplanted onto the area affected by periodontal disease so that the lost periodontal tissue can be regenerated.